［Key words］ ultrasonography,doppler; drug toxicity; breast neoplasmas; myocardial performance index; adriamycin
To explore the application value of spectra Doppler Tei index in judgement of adriamycin-induced myocardial toxicity in breast cancer patients when treated with this medicine. Methods: A total of 102 cases of breast cancer patients were divided into three groups: group A (26 cases, received adriamycin <300 mg/m2), group B (26 cases, received adriamycin≥300 mg/m2) and group C (50 cases, no adriamycin was used). All the patients were checked and the Tei index and conventional echocardiographic parameters were obtained. Simultaneously, electrocardiogram and myocardial enzyme activities of the patients with chemotherapy were recorded. Results: No significant difference of conventional echocardiographic or Tei parameters was found between groups A and C (P>0.05); LVEF, FS and ET were conspicuously lower in group B than those in groups A and C (P<0.05); IRT, ICT/ET, IRT/ET and Tei index were significantly higher in group B than those in groups A and C (P<0.05). Tei index detection rates were corresponding with those of myocardial enzyme detection in breast cancer patients with myocardial toxicity caused by adriamycin treatment (P<0.05). Conclusion: Tei index is valuable in evaluation of adriamycin-induced myocardial toxicity of breast cancer patients treated with the medicine.
