The Content Changes of Plasmic NPY, NE, DA, and 5-HT and Their Significancein Patients with Coronary Heart Disease Accompanied by Anxiety
［Key words］ coronary disease; anxiety disorders; neuropeptide Y; norepinephrine; dopamine; 5-hydroxytryptamine
To explore the content changes of plasmic neuropeptide Y (NPY), norepinephrine (NE), 5-hydroxytryptamine (5-HT), dopamine (DA) and their clinical significance in patients with coronary heart disease (CHD) accompanied by anxiety. Methods: Seventy-one patients with CHD，diagnosed with selective coronary arteriongraphy method, were divided into anxiety group and control group by Self-Rating Anxiety Scale（SAS）. The times and days of hospitalization of these patients were recorded. Levels of plasmic NPY, NE, DA and 5-HT were detected by using radioimmunoassay and immumofluorescence methods in all of the patients. Results: (1) The numbers of time and day in hospital of patients in group A were bigger than those of patients in group B (P<0.05); (2) The levels of plasmic NPY, DA, NE, and 5-HT of patients in group A were significantly higher than those of patients in group B (P<0.05). Conclusions: (1) The increase of hospitalization times and days of CHD patients accompanied by anxiety should cause the attention of clinical doctors specially doctors of cardiovascular diseases; (2) The unusual increase of plasmic NPY, DA, NE, and 5-HT indicates that they might be involved in the pathophysiologic process of anxiety accompanied CHD.
