An Ultramicroscopy Observation of Protective Effects of Triterpenoids from Ganoderma lucidum on Brain of Alzheimer Disease Model Rats
［Key words］ Gardenia; Alzheimer disease; hippocampus; malondialdehyde; microscopy,electron，scaning transmission; rats,sprague-dawley
To observe the protective effects of triterpenoids from Ganoderma lucidum (GLT) on the modality of hippocampus tissue of Alzheimer disease (AD) model rats．Methods: AD rats induced by injection of Aβ25-35 into one side of hippocampus were treated with GLT orally for 20 days and then ultrastructural changes of neurons were observed under transmission electron microscope．Results： The modality of hippocampus CA1 region neurons of GLT treated AD rats was distinctly improved when compared with that of the model rats that did not receive GLT treatment．Conclusion: GLT can improve recessively changed neurons in hippocampus CA1 region．
