［Key words］ immunoglobulins; immunoglobulin G; respiratory tract infections; child
To explore the relation of recurrent respiratory tract infection (RRTI) with serum levels of immunoglobulin and IgG subclasses, and to provide theorical basis for RRTI treatment. Methods: Serum levels of IgG, IgA, IgM and IgG subclasses of 28 RRTI (18 males and 10 females ) children and 15 normal children (5 males and 10 females) were determined with immuno-scattered turbidity method, and the data were analyzed. Results: There was no significant difference of levels of IgG and IgA between RRTI group and control group(P＞0.05)； Serum level of IgM of RRTI group was significantly lower than that of control group (P＜0.05)； Serum levels of IgG2 and IgG4 in RRTI group were significantly lower than those of control group（P＜0.05, P＜0.01). Conclusion： there is immune disorder to some degree in children with RRTI. To detect serum levels of immunoglobulin and IgG subclasses in children with RRTI could increase correct diagnosis rate.
